Regulus(美國)

Regulus Therapeutics

美國RegulusTherapeuticswww.regulusrx.comRegulus公司始建于2007年是由Alnylam與Isis兩家制藥公司聯(lián)合創(chuàng)建的。心血管/代謝性疾病項目中擬用于治療動脈粥樣硬化的靶位microRNA-33。RegulusisfocusedonthediscoveryanddevelopmentofmicroRNAtherapeutics.microRNAsareme mbersofalargeclassofnon-codingRNAsofapproximately22nucleotidesinlengththatregulatemostgenesinthegenome.AsinglemicroRNAcantargetandregulateuptohundredsofgenes,andthesegenesareinvolvedinbiologicalnetworksorpathways.DysregulatedmicroRNAexpressionisinvolvedintheinitiationofmanycomplexmulti-factoraldiseases,includingcancer,inflammatorydisease,fibrosis,andmetabolicdis